FIG. 7.

Cross-priming of T_CD8⁺ dictates antigen requisites. (A) RMA-HHD cells were infected with MVA-Tyr or wild-type MVA (MVA-wt) and coincubated with Tyr_1-9-reactive CTL. Specific activation of T_CD8⁺ was assessed by intracellular staining for IFN-γ production. (B) Groups of A*0201 mice (n = 4) were vaccinated with MVA-Tyr or with the Tyr_1-9 peptide. Representative plots from intracellular IFN-γ staining on day 8 postvaccination are depicted. Data are representative of three independent experiments.