TABLE 1.
Clinical and pathological outcomes for ferrets in the challenge experiment
| Primary infection and ferret no. | Challenge virus | Severity of clinical sign (after primary infection [first group] or after challenge)a
|
Animal classified as moribund on day: | Severity of pathology findings (at postmortem [first group] or at the end of the expt)a
|
Immune status indicator (at 2 weeks postinfection [first group] or on the day of challenge)a
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hyperthermia | Rash/ erythema | Purulent discharge | Lymphopenia | Lung lesions | Intoxication | Lymphoid depletion | DTH | PBMC proliferation | Neutralizing antibodies | |||
| rCDV5804P | ||||||||||||
| 12 | None | +++ | +++ | +++ | +++ | 15 | +++ | +++ | +++ | − | − | − |
| 21 | None | +++ | +++ | +++ | +++ | 18 | +++ | +++ | +++ | − | − | − |
| 19 | None | +++ | +++ | +++ | +++ | 18 | +++ | +++ | +++ | − | − | − |
| 20 | None | +++ | +++ | +++ | +++ | 16 | +++ | +++ | +++ | − | − | − |
| rCDV5804P-L-CCegfpC | ||||||||||||
| 15 | rCDV5804P | − | − | − | − | − | − | − | − | + | + | − |
| 16 | rCDV5804P | − | + | − | ± | − | − | − | + | + | + | − |
| 11 | rCDV5804P | − | + | − | + | − | + | − | ± | + | + | − |
| 24 | rCDV5804P | − | + | − | − | − | − | − | ± | + | − | + |
| 13 | rCDV5804P | +++ | ++ | ++ | +++ | 22 | +++ | ++ | +++ | − | − | − |
| 10 | rCDV5804P | ± | + | − | + | − | + | − | + | + | − | − |
| rCDVOP | ||||||||||||
| 6 | rCDV5804P | − | − | − | ++ | − | + | − | ± | + | + | ± |
| 18 | rCDV5804P | − | − | − | ++ | − | + | − | ± | + | − | + |
| 9 | rCDV5804P | − | − | − | ± | − | − | − | − | + | + | − |
| 3 | rCDV5804P | − | − | − | − | − | − | − | − | + | + | + |
| 4 | rCDV5804P | − | − | − | − | − | − | − | − | + | + | + |
a
+++, severe; ++, moderate; +, mild; ±, unclear; −, absent.