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Transrepression activity of GR isoforms. (A) All GR isoforms dose-dependently downregulated NF-κB reporter gene expression. (B) All GR isoforms inhibited LPS-induced expression of TNF, IL-8, and granulocyte-monocyte colony-stimulating factor (GMCSF) in U-2 OS cells. One-way ANOVA was performed to compare values from different treatments, which was followed by Tukey post hoc analysis. y-axis values are percentages. *, significantly different from that of LPS treatment (P < 0.05).
