FIG. 5.

Widespread and selective gene regulation by GR isoforms. (A) Clustering analysis of the 6,501 genes regulated by at least one GR isoform after 6 h of DEX treatment. The gene targets of each GR isoform are diverse and distinct. (B) Each of the GR isoforms regulated a unique set of genes. The numbers of genes induced (red) or repressed (blue) by each isoform are shown. Dotted lines mark the number of genes regulated by all isoforms. (C) Clustering analysis of 301 genes involved in cell death indicated that the majority of these genes were selectively regulated by GR isoforms. As highlighted by the brackets, GR-D isoforms did not regulate a series of genes as robustly as the other GR isoforms.