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. 2007 Aug 6;27(20):7143–7160. doi: 10.1128/MCB.00253-07

TABLE 1.

Changes (n-fold) in genes regulated by GR isoformsa

Entrez gene ID Gene Fold change
GRα GRα-A GRα-B GRα-C GRα-D
2 A2M 1.47 2.28* 3.26* 3.40* −1.13
9625 AATK 1.20 3.29* 1.63* 2.69* 1.75
25 ABL1 −2.10* −1.88 −1.99* −2.23* −1.29
87 ACTN1 −1.27* −1.29* −1.30* −1.23 −1.09
88 ACTN2 9.88 11.08* 3.58* 5.77* −1.35
150209 AIFL 1.00 8.87* 1.45 1.94 16.94*
207 AKT1 −1.53 −1.76 −1.48 −1.51* −1.18
208 AKT2 −1.58* −1.26 −1.27* −1.37 −1.12
347902 AMIGO2 −18.86* −19.68* −15.26* −9.55* −24.43*
51129 ANGPTL4 −7.33 −11.44* −3.76 −10.84 1.15
348 APOE 2.42* 1.37 1.40 1.76* 1.55
80833 APOL3 1.22 −1.06 1.27 2.08* −1.11
54840 APTX −1.71* −1.39* −1.20 −1.44* 1.14
51742 ARID4B −1.34 −1.32 −1.14 −1.39* −1.37
9140 ATG12 −1.05 1.00 1.20* 1.28* 1.19
23192 ATG4B 1.37 1.43* 1.19 1.34* 1.19
6310 ATXN1 −3.70* −4.70* −3.27* −3.58* −3.21
6311 ATXN2 −1.27 −1.31 −1.34* −1.49 −1.09
64651 AXUD1 −3.65* −3.01* −1.70* −3.53* 1.36
573 BAG1 −1.42 −1.39* −1.14 −1.40 1.02
9532 BAG2 −3.20* −2.26* −1.68* −2.11* −1.33
9531 BAG3 −1.88* 1.19* 1.71* 1.23 1.38
9530 BAG4 −1.11 −1.51 −1.27 −1.38* −1.24
580 BARD1 1.37* 1.43* 1.34 1.08 1.35
8915 BCL10 1.60* 1.27 1.02 1.15 1.02
598 BCL2L1 −4.28* −2.94* −2.86* −2.56* −1.46
10018 BCL2L11 −1.24 −1.85 −1.65* −1.65 −1.42
79370 BCL2L14 2.57* 3.74 8.47* 1.86 −1.23
599 BCL2L2 −1.92* −1.63* −1.47* −1.99* −1.02
54880 BCOR −1.58 −1.73 −1.56* −1.93* −1.61
274 BIN1 −1.21 −1.29* −1.14 −1.21 1.23
4671 BIRC1 1.57 1.72* 1.21 1.18 −1.43
90427 BMF −2.65 −3.24* −2.41 −3.33 −1.82
665 BNIP3L −1.04 −1.15 −1.28 −1.23 −1.63*
666 BOK −1.96* −1.98* −1.61 −1.90* 1.11
673 BRAF −1.45* −1.67* −1.19 −1.48* −1.14
672 BRCA1 −1.11 1.19* 1.31 −1.16 1.08
9577 BRE −1.23 −1.21 −1.32* −1.14 1.09
54014 BRWD1 −1.63 −2.07 −1.98* −2.09 −1.54
694 BTG1 1.78* 1.01 −1.17 −1.27 −1.93
695 BTK −1.18 2.74 12.53 6.34* 5.92
81566 C12orf22 2.13* 1.87 1.29 1.76 1.04
114897 C1QTNF1 1.64 2.15* 2.35 4.33* 4.75
114898 C1QTNF2 −2.04* −2.14* −1.44* −1.93* −1.30*
114900 C1QTNF4 −1.08 1.11 −2.03 1.24 9.70*
114905 C1QTNF7 −1.19 −1.31 1.33 −1.06 4.08*
56997 CABC1 −1.49* −1.60 −1.63 −1.41 −1.52
824 CAPN2 −1.05 −1.39 −1.39 −1.62* −1.31
29775 CARD10 −5.71* −5.47* −2.30* −3.68* −1.26
58484 CARD12 5.11* 1.46 4.85* 19.79* −1.03
79092 CARD14 20.55* 59.49* 83.31* 55.19* 50.25*
64127 CARD15 4.09* 1.82 2.14 4.88* 1.99
84674 CARD6 −3.45* −3.67* −3.22* −3.64* −2.11
843 CASP10 −1.21 −1.80 −1.98* −1.28 −1.20
837 CASP4 −1.12 −1.13 −1.33* −1.17 −1.11
839 CASP6 3.33* 3.14* 2.19* 3.13* 1.35
840 CASP7 1.58 1.52* 1.93* 1.52* 1.29
842 CASP9 −1.36* −1.45* −1.34* −1.62* 1.00
8535 CBX4 1.77* 1.54 1.36 1.59 1.33
55749 CCAR1 1.37* 1.56* 1.34* 1.33 1.11
6347 CCL2 −8.54* −27.25* −17.58* −12.81* −12.28*
952 CD38 1.46 1.82 4.06* 8.12* 10.30
959 CD40LG 1.35 5.73 1.16 1.98 11.02*
984 CDC2L1 1.28* 1.37* 1.16 1.34* 1.16
1026 CDKN1A 1.03 1.47 1.35* 1.59* 1.25
114548 CIAS1 2.62 8.33* 14.20* 6.44* 5.99*
1149 CIDEA 5.86* 2.96 1.66 3.96 8.28
63924 CIDEC 1.08 1.29 1.81* 1.67* 1.34
26586 CKAP2 1.09 −1.03 1.45* −1.19 1.11
23529 CLCF1 −4.41* −4.30* −3.96* −5.37* −1.71
1196 CLK2 −1.02 1.44* 1.40* 1.41* 1.39
23603 CORO1C −1.47 −2.15* −1.41 −1.69 −1.61
7464 CORO2A −1.83* −2.20* −1.67* −1.94* −1.61
56259 CTNNBL1 1.05 1.33* 1.30 1.37 1.36
8454 CUL1 −1.56* −1.18 −1.05 −1.28* 1.06
8451 CUL4A 1.65* 1.38* −1.07 −1.10 −1.15
1603 DAD1 1.22* 1.19* 1.14* 1.18 −1.08
1605 DAG1 −1.35 −1.32 −1.36 −1.45* −1.14
23604 DAPK2 1.96 1.85* 1.75 1.51 2.29
1613 DAPK3 −2.62* −1.97* −1.63 −1.60 1.33
1616 DAXX −1.69* −1.70* −1.53* −1.73* 1.02
162989 DEDD2 −2.05 −1.59* −1.18 −1.73 1.07
56616 DIABLO −1.24* −1.17 −1.26 −1.19 −1.12
55929 DMAP1 1.15 1.41* 1.32* 1.55* 1.46*
1776 DNASE1L3 7.79* 31.29* 28.11* 25.78* 8.78*
5977 DPF2 −1.25 −1.54 −1.53 −1.87* −1.17
29952 DPP7 1.31 1.46* 1.01 1.52 1.24
80824 DUSP16 −3.52* −2.38* −1.86* −2.29* −1.32
56940 DUSP22 −1.08 −1.15 −1.23* −1.18 −1.27
8655 DYNLL1 −1.66* −1.59* −1.18* −1.85* −1.08
140735 DYNLL2 1.42* 1.67* 1.71* 1.63* 1.32
9166 EBAG9 1.05 1.36* 1.42* 1.28 1.02
63916 ELMO2 1.18 1.46* 1.74* 1.35 1.72*
55531 ELMOD1 5.20* 3.95* 6.43* 4.41* 1.36
255520 ELMOD2 1.57* 1.36 1.31* 1.29 −1.32
2012 EMP1 −4.05 −4.26* −4.14* −5.78 −5.81*
8507 ENC1 −2.36* −3.58* −6.96* −2.42* −3.68*
2021 ENDOG 1.65* 1.53* 1.29 1.40 1.74*
2056 EPO −1.20 1.42 −1.10 2.09 24.80*
2081 ERN1 2.84 4.79* 5.01* 9.08* 5.58
2149 F2R −2.08* −2.05* −2.37 −1.49 −3.19
8772 FADD 1.07 −1.16 −1.02 −1.29* 1.07
79675 FASTKD1 1.73* 1.58 1.19 1.40 1.05
22868 FASTKD2 −1.64* −1.13 −1.07 −1.18 −1.22
60493 FASTKD5 1.24* 1.28 1.48* 1.46 1.13
2309 FOXO3A 1.85* 1.99* 1.60* 2.01* 1.28
64400 FTS −1.10 −1.31* 1.42* −1.21 −1.03
2549 GAB1 2.65* 1.76 1.63 1.61 −1.32
1647 GADD45A −2.13* −1.52 −1.09 −1.23 −1.09
4616 GADD45B 1.30 1.40 −1.05 1.89* −1.20
11010 GLIPR1 −1.75 −1.29 −1.22 −1.12 −1.46*
9340 GLP2R −1.73* −2.57* −1.51 −1.92* −2.23
2752 GLUL −1.04 1.88 5.67* 1.24 2.14
8477 GPR65 −8.21* −1.06 −1.03 −16.13* −2.07
51454 GULP1 −1.99 −1.04 −1.67* −1.52 −2.00*
3001 GZMA 28.18* 22.25* 9.29* 11.66* 3.69
3093 HIP2 −1.37* −1.37* −1.37* −1.59* −1.15
3192 HNRPU −1.48 −1.44 −1.26 −1.59* −1.15
10524 HTATIP −2.25* −1.45 −1.16 −1.31 1.13
135458 HUS1B 2.35* 1.41 1.38 2.10* −1.13
8870 IER3 −3.93* −10.03* −8.18* −5.28* −4.94*
2537 IFI6 1.28 −1.00 −1.08 1.17 −1.44*
64135 IFIH1 1.91* 1.25 −1.35 1.27 −1.03
55764 IFT122 1.38* 1.47* 1.39* 1.76* 1.17
3480 IGF1R −2.80* −2.71* −1.91* −2.05* −1.88
117283 IHPK3 1.71 3.96 12.07* 6.75 3.01
3551 IKBKB −1.30* −1.36 −1.37* −1.35* 1.09
3600 IL-15 −1.59* −1.93* −1.52* −2.18* −1.91
3601 IL15RA −1.74 −2.08 −2.08* −1.77 −1.90
3606 IL-18 −2.31 −2.47* −2.04* −1.79 −2.76*
3553 IL1B 1.15 −5.87* −4.83 −4.92 −1.56
56300 IL1F9 2.47 3.02 5.82* 8.37* 1.18
3556 IL1RAP 1.05 −1.64* −1.67* −1.70 −1.62
11009 IL-24 −3.24 −4.56* −1.27 −2.41 −2.31
3563 IL3RA 7.39 2.82 4.60* 2.36 1.72
3575 IL7R −3.73* −2.65* −2.03 −1.46 −3.25*
3621 ING1 2.95* 2.91* 2.11* 1.65* 1.39
3622 ING2 −1.29 −1.58* −1.11 −1.68* 1.01
54556 ING3 1.36 1.29 1.41* 1.19 1.07
3624 INHBA −5.24* −4.36* −2.29* −2.36* −2.87
3659 IRF1 −1.37 −1.96* −1.47 −1.53 −1.15
3689 ITGB2 13.94 6.29* 15.50* 20.21* 1.46
3727 JUND −2.42* −2.25* −2.20* −2.33* −1.46*
85329 LGALS12 5.06* 7.51* 4.59* 15.62* −1.08
3964 LGALS8 −1.18 −1.22* −1.13 −1.18 −1.35*
4050 LTB 1.47 −1.29 −1.89* −1.12 −1.52
10296 MAEA 1.24* 1.28* 1.18* 1.10 1.07
260425 MAGI3 −1.28 −1.35 −1.40* −1.42* −1.40
4118 MAL 7.83* 1.61 6.49* 4.05 2.49
10892 MALT1 −1.83 −1.65* −1.32 −1.70 −1.66*
9020 MAP3K14 −2.63* −2.48* −2.17* −2.76* −2.04*
6885 MAP3K7 1.69* 1.66* 1.34 1.43 −1.03
891 MAP4K3 −1.39* −1.29 −1.21 −1.35 −1.15
5594 MAPK1 −1.32 −1.36* −1.13 −1.39* −1.05
5601 MAPK9 −1.49 −1.96* −1.46* −2.08* −1.48*
4149 MAX −1.41* −1.49* −1.36* −1.67* −1.11
4170 MCL1 −1.74* −1.73* −1.45* −2.27* −1.14
4194 MDM4 −1.32* −1.14 −1.21* −1.38 −1.17
145815 MGC18216 −1.81 −2.71* −2.07 −2.24 −2.60*
64112 MOAP1 −1.51 −1.70 −1.34* −1.88* 1.02
27136 MORC1 1.29 2.37 3.00* 2.59 −1.86
4488 MSX2 4.03* 3.00* 3.48* 3.15* 3.23*
9633 MTL5 1.71* −1.15 −1.27 −1.31 −1.21
4615 MYD88 1.62* 1.15 −1.21 1.12 1.03
338322 NALP10 −7.19* −3.06 −3.54 −2.59 2.35
4790 NFKB1 −2.24* −2.06* −1.52 −1.50* −1.27
4791 NFKB2 −1.67 −1.98* −1.56 −1.10 −1.40
4792 NFKBIA 1.69 1.97 5.44* 2.28 2.10
4804 NGFR 3.09* 2.89 1.90 2.64* 1.28
8382 NME5 5.79* 2.02 1.15 1.69 2.20
4836 NMT1 1.61* 1.42* 1.37* 1.59* 1.17
8996 NOL3 2.32* 2.79* 3.19* 3.10* 1.61
9542 NRG2 12.11* 17.48* 27.26* 37.45* 2.70
8439 NSMAF −1.48* −1.49* −1.55* −1.71* −1.10
4908 NTF3 9.21* 15.28* 21.25* 27.51* 10.31*
4914 NTRK1 −1.14 −1.85 1.12 1.13 3.00*
4973 OLR1 −1.06 −5.94* −2.06 −2.60 −6.60
51237 PACAP −1.46 4.49 1.28 −1.41 13.10*
5058 PAK1 −1.21 −1.32 −1.33 −1.49* 1.01
5062 PAK2 −1.41* −1.27* −1.45* −1.50* −1.20
56924 PAK6 3.28* 1.83 2.14 2.71 2.23
143 PARP4 1.63* 1.83* 1.53 1.89* 1.54
5074 PAWR −2.48* −2.46* −2.80* −1.45 −2.44*
5077 PAX3 −1.03 1.90 −1.06 −1.04 11.51*
10135 PBEF1 −2.02* −1.45* −1.02 −1.54* 1.03
80380 PDCD1LG2 −1.45 −3.98 −4.19* −2.92 −1.60
27250 PDCD4 −1.58* −1.86* −1.70 −1.91* −2.03*
10081 PDCD7 1.21 1.34* 1.16 1.08 1.25*
79031 PDCL3 −1.14 −1.14 −1.01 −1.43* −1.02
8682 PEA15 −1.74* −1.78* −1.73* −1.77* −1.47
79960 PHF17 −2.54 −2.36* −1.58 −2.63* −1.11
7262 PHLDA2 1.62* −1.10 −1.13 −1.35 −1.14
5291 PIK3CB −1.97* −1.92* −1.51 −2.45* 1.08
5293 PIK3CD 1.42 1.22 1.52* 1.12 1.64*
5295 PIK3R1 1.11 1.60 1.76* 1.48 1.22
8503 PIK3R3 1.98* 1.97 −1.19 1.65 1.07
5325 PLAGL1 2.00* 1.38 −1.04 1.30 −1.31
79156 PLEKHF1 −1.30 −1.08 1.38 1.02 1.27*
57645 POGK −2.06* −1.87* −1.31 −2.03* −1.19
10848 PPP1R13L −2.18* −2.32* −1.97* −1.80* −1.73*
23645 PPP1R15A −1.53 −1.42 −1.43* −1.34 1.08
5515 PPP2CA −1.36* −1.70* −1.18 −1.52* −1.18
5519 PPP2R1B −1.51* −1.43 −1.24 −1.27 −1.29
5530 PPP3CA −1.38 −1.59* −1.68* −1.77* −2.10*
5533 PPP3CC 4.49* 3.39* 3.17* 4.71* 1.77
5534 PPP3R1 −1.88 −1.99* −1.52* −2.25* −1.40
5552 PRG1 −1.07 1.34 2.35* 2.15* 1.22
5567 PRKACB 1.16 −1.61* −1.40* −1.69* −1.84
5573 PRKAR1A −1.18* −1.54* −1.32* −1.51* −1.37*
5575 PRKAR1B 2.25* 2.93* 2.30* 1.35 2.57*
5579 PRKCB1 6.97* 4.64* 12.54* 14.91* 1.99
5580 PRKCD 2.35* 1.99* 1.29* 1.64 −1.03
5581 PRKCE −1.05 1.75* 1.68* −1.23 −1.24
5584 PRKCI 1.12* 1.01 −1.08 1.07 −1.47*
5618 PRLR 2.09 2.08 1.69 7.73* 1.03
5663 PSEN1 −1.15 −1.38 −1.51* −1.43 −1.41*
23210 PTDSR −2.09* −1.23 1.05 −1.51 1.68*
2185 PTK2B 2.20* 2.38* 2.34* 2.22* 2.63
51651 PTRH2 −1.31 −1.83* −1.51* −1.69* −1.67*
5885 RAD21 −1.52* −1.32 −1.15 −1.44* −1.31
84173 RBED1 1.64* 1.55* 1.28 1.23 1.32
5939 RBMS2 −1.52 −1.97* −1.69* −1.63* −1.96*
27303 RBMS3 1.54 1.56 1.96* 1.87 1.42
5970 RELA −1.60* −1.62* −1.50* −1.49* −1.09
473 RERE 2.53* 2.22* 2.55* 2.82* 1.31
388 RHOB 1.40 1.57 2.23* 1.78 1.86
8737 RIPK1 2.55* 2.06* 1.55 2.32* 1.24
8767 RIPK2 −1.70* −2.19* −2.23* −2.23* −1.31
152006 RNF38 −1.24* −1.31 −1.27* −1.62* −1.51
6093 ROCK1 −1.28* −1.09 −1.29* −1.40* −1.22
64121 RRAGC 1.68* 1.51* 1.47* 1.51* 1.25*
57142 RTN4 −1.95 −1.77* −1.78* −1.53 −1.97
29115 SAP30BP 1.11 1.15 1.34 1.17 1.50*
949 SCARB1 −1.39 −1.43* −1.28* −1.38 −1.47
6446 SGK 3.83* 8.86* 11.78* 7.14* 5.52*
8879 SGPL1 −1.28 −1.24* −1.20 −1.38* −1.36
81537 SGPP1 2.00* 1.09 1.22 1.11 −1.48
51100 SH3GLB1 −1.15 −1.08 −1.08 −1.33* −1.14
30011 SH3KBP1 −1.25 −1.43 −1.53* −1.39 −1.40*
6477 SIAH1 −1.72* −2.26* −1.43 −2.73* −1.16
6478 SIAH2 −1.89* −1.36 −1.09 −1.60* 1.47
4086 SMAD1 −1.67* −1.91* −1.59* −2.57* −1.72
6622 SNCA −1.22 −1.89 −1.69 −1.69 −1.61*
6651 SON −1.92 −1.64* −1.48 −2.18 −1.31
6659 SOX4 −1.68 −2.05 −2.62* −2.48 −1.94
56928 SPPL2B 1.58 1.59* 1.26* 1.71* 1.24
6774 STAT3 1.26* 1.10 1.25 1.28 1.03
6776 STAT5A 3.40* 5.84* 2.30* 3.54* 1.48*
6778 STAT6 −1.43 −1.53* −1.53 −1.22 −1.59
9262 STK17B 1.41* −1.05 1.31 −1.24 −1.23
6613 SUMO2 −1.27* −1.57* −1.32* −1.63* −1.29*
10474 TADA3L −1.08 −1.23* −1.12 −1.40 −1.02
55145 THAP1 −1.14 −1.54* −1.26 −1.40 −1.40
7078 TIMP3 3.07* 1.31 −1.71 1.23 −1.87
7096 TLR1 −2.32* −3.13 −1.88 −2.65 −2.23
7100 TLR5 9.41* 3.91* 1.55 1.64 15.93
83877 TM2D2 −1.87 −1.56 −1.29 −1.99* −1.39
80213 TM2D3 1.50 1.46* 1.36* 1.29 1.03
7126 TNFAIP1 −3.04* −3.00* −2.22* −3.62* −1.71*
7127 TNFAIP2 −1.36 −2.79* −3.57* −2.19 −2.28*
7128 TNFAIP3 −1.87 −1.17 1.53* −1.04 1.67
7130 TNFAIP6 −1.26 −5.24 −5.37* −2.48 −2.42
25816 TNFAIP8 1.69* 1.28 1.44 −1.02 −1.16
8797 TNFRSF10A −1.58 5.65 1.83 3.42 16.84*
8795 TNFRSF10B 2.03* 2.42* 2.32* 2.53* 1.32
4982 TNFRSF11B −1.83* −3.20* −6.10* −2.97* −4.51*
51330 TNFRSF12A −5.75* −3.80* −2.99* −3.62* −2.00*
84957 TNFRSF19L 4.19* 3.83* 2.89* 3.80* 1.52
7132 TNFRSF1A 1.02 −1.01 −1.14 −1.35* 1.15
7133 TNFRSF1B 11.94* 8.06* 17.13* 9.73* 6.81*
27242 TNFRSF21 −1.22 −1.82* −1.39* −1.86* −1.85
8718 TNFRSF25 −1.90* −1.53 −1.50* −1.81 −1.37
943 TNFRSF8 −2.96 −2.83* −1.33 −1.12 −1.83
8600 TNFSF11 1.48 7.84 1.14 1.33 13.51*
8740 TNFSF14 1.44 7.54* 1.02 6.66* 7.59
7292 TNFSF4 5.62* 5.42* 3.73 7.57* 1.68
56984 TNFSF5IP1 −1.44* −1.40* −1.31* −1.55* −1.21
970 TNFSF7 −2.01* −1.97 −2.33* −1.17 −3.18*
8744 TNFSF9 −1.20 −1.30 −2.85* −1.22 −1.35
7159 TP53BP2 1.35 1.57 2.09* 1.39 2.64*
9540 TP53I3 2.91* 5.57* 4.43* 5.71* 1.77*
7185 TRAF1 −2.43* −5.25* −1.55 −1.47 −2.13
7187 TRAF3 −2.33* −2.28* −1.78* −2.66* −1.54
10758 TRAF3IP2 2.40* 2.00* 3.08* 2.80* 2.24
9618 TRAF4 −3.47* −3.89* −2.64* −3.17* −1.00
7188 TRAF5 3.29 3.26* 2.30* 1.69 1.17
57761 TRIB3 −3.53* −3.43* −2.14* −2.81* −1.19
80263 TRIM45 1.91* 2.03* 1.65* 1.47* 1.39
10497 UNC13B 1.13 1.41* 1.58* 2.23* 1.47
55759 WDR12 −1.63 −1.51* −1.24 −1.51 −1.44*
80232 WDR26 −1.20 −1.41* −1.36 −1.57* −1.50
10885 WDR3 −1.49* −1.64* −1.50* −1.62* −1.54*
114987 WDR31 1.33 1.71 1.58 1.43 1.74*
22884 WDR37 2.56* 2.65* 1.70* 2.23* 1.35
139170 WDR40B 1.61* 1.97* 3.06* 2.25* 1.36
11180 WDR6 −1.75* −1.44* −1.37 −1.59 −1.14
7532 YWHAG −1.79* −1.72* −1.54* −1.85* −1.21
7533 YWHAH −1.55* −1.99* −1.42 −2.20* −1.15
7534 YWHAZ −1.35* −1.56* −1.38* −1.57* −1.35*
51776 ZAK −2.11* −2.18* −1.55* −2.29* −2.03*
23567 ZNF346 −1.12 −1.13 −1.09 −1.31* 1.05
a

This list was generated by gene ontology cell death and regulated by at least one GR isoform (*, P < 0.0001). There are 301 genes in the list, 25 of which are regulated by all GR isoforms (highlighted in boldface type).