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Loss of Notch signaling causes small-lens phenotype in mice. (A) LacZ reporter expression in Le-Pax6-Cre/R26R mice. (B) A section through the stained region shown in panel A. (C) A P14 Rbp-J+/Flox mouse. (D) A P14 Rbp-Jflox/d/Le-Pax6-Cre mouse. (E) Postnatal lenses in control and Rbp-J mutant mice at P0, P15, and P30. Scale bars, 250 μm.
