FIG. 6.
Notch signaling suppresses the differentiation of primary lens fiber cells. (A) Sections across the eye region in E11.5 control and Rbp-J mutant embryos were immunostained for p57Kip2 and Jag1. Arrows indicate some of the control cells that do not express p57Kip2. (B) Quantification of BrdU incorporation in control and mutant lens vesicles. Error bars indicate standard deviations. *, P value was <0.05. (C) In situ hybridization of Herp2 in sections of E11.5 control and mutant eyes. (D) Immunostaining of β-crystallin in sections of E11.5 control and mutant eyes. Scale bars, 50 μm.