TABLE 1.

Antibiotic susceptibilities of the OmpU mutants

Antibiotic	Mol wt	Diam (mm) of zone of inhibition for cells expressing:a
		WT	R27D	R27A	R46A	R86A	D116N	D116A	E127Q	E127A	G122Q	R134A
Cefaclor	368	32	28	30	30	29	28	28	29	30	28	30
Cefadroxil	364	20	19	20	19	19	19	19	18	20	19	20
Cefotaxime	477	44	40	39	40	40	40	36	40	39	40	42
Cefoxitin	450	23	21	24	22	21	22	23	23	22	22	23
Cefamandole	484	31	27	28	29	28	28	27	28	28	27	31
Ceftazidime	546	32	30	29	29	29	30	28	30	30	30	30
Ceftriaxone	598	38	35	36	37	33	37	32	36	36	38	36

^aMeasurements were done on three individual colonies and averaged. The antibiotic disc diameter was 6 mm. Bold values represent a greater-than-average resistance to the antibiotic. Standard errors are less than 3%.