TABLE 1.
Characteristics of the HIV-1- and HIV-2-infected patients and healthy controls studied
| Characteristic | Value for groupa
|
|||||
|---|---|---|---|---|---|---|
| Controls
|
HIV-1-infected patients
|
HIV-2-infected patients
|
||||
| 35 to 45 yr | >45 yr | 35 to 45 yr | >45 yr | 35 to 45 yr | >45 yr | |
| No. of subjects | 11 | 12 | 6 | 9 | 7 | 13 |
| Ethnicityb | 9 C, 2 A | 11 C, 1 A | 5 C, 1 A | 6 C, 3 A | 4 C, 3 A | 7 C, 6 A |
| Age (yr)c | 39 (36-45) | 54 (46-65) | 41 (35-43) | 54 (46-65) | 38 (35-45) | 49 (46-68) |
| Time (mo) after first seropositivityc,d | NA | NA | ND | ND | 19 (7-133) | 18 (2-172) |
| Viral load (log copies/ml)c | NA | NA | 4.06 (2.63-4.98) | 4.55 (3.28-5.41) | <200e | <200e (<200-4,006) |
| Absolute CD4 count (cells/ml)c | 920 (535-1,867) | 882 (347-1,758) | 291** (92-704) | 240** (88-986) | 927 (333-1,184) | 593* (220-830) |
| Absolute CD8 count (cells/ml)c | 336 (105-1,236) | 265 (99-770) | 654* (269-2,007) | 781** (518-2,210) | 845* (611-1,778) | 670** (202-2,180) |
The subjects are grouped by disease status (controls and HIV-1- and HIV-2-infected patients) and age. NA, not applicable; ND, not determined. Statistical differences between the values for HIV-infected patients and age-matched controls (Mann-Whitney test) are indicated as follows: *, P < 0.05; **, P < 0.01.
The number of Caucasians (C) and Africans (A) are shown (all the African subjects had been residing in Europe for several years at the sampling time).
The median value is shown, and the range is shown in parentheses.
All the HIV-2-infected individuals were identified as seropositive at their first visit. (The HIV-1 patients were sampled for another cross-sectional study.)
HIV-2 viremia was quantified by a reverse transcriptase PCR-based test; all but one of the HIV-2 infected patients had a viral load below 200 RNA copies/ml (cutoff value).