FIG. 3.

vMyxIL-12 pathogenesis in rabbits. Three rabbits were infected with vMyxIL-12, two rabbits with vMyx, and two rabbits with vMyxgfp. The rabbits were each infected with 2,000 FFU, with 1,000 FFU injected into each hind flank. Rabbits were monitored daily for the clinical symptoms associated with myxomatosis. Scores increase as the disease progresses. Animals are normally sacrificed within 24 to 48 h following a score of 15. Certain symptoms, such as severe orthopnea, mouth breathing, cyanosis, and lack of food and/or water intake for >24 h, required that the rabbits be euthanized for ethical reasons.