TABLE 1.

Pathogenicity of vMyxIL-12 mutant MV in European rabbits

Day(s) postinfection	Pathogenicity of mutant:
	vMyx (2 animals)	vMyxgfp (2 animals)	vMyxIL-12 (3 animals)
4	Primary lesion red, raised, 0.5 cm	Primary lesion red, raised 0.5 cm	Primary lesion just visible, small, flat, pink
7	Large protuberant lesion, 2.5 cm; eyelids red and swelling, lesion beginning; satellites (2-4) around primary lesion; lesions beginning in ears (2-3 each ear)	Primary lesion, 1.5 cm, protuberant; ruffled fur, satellites visible; ear lesions (4-5), ears turning purple; lesions visible on eyelids	Primary lesion dark red, not protuberant, 1.0-2.0 cm; single, small lesions may be appearing in ears
8	Primary lesion larger, 2.5-3.0 cm, starting to cavitate; head swollen; lesions around nose and muzzle; ears purple, swollen, and heavy, secondary lesion visible	Large protuberant primary lesion; head swollen; multiple ear lesions, purple; 1-2 lesions on nose; multiple lesions on eyelids	Primary lesion flattened, 1.0-2.5 cm, lot of fur overgrowing lesion; 1-2 lesions starting on eyelids; 1 animal with 3-5 lesions in ears
9-11	Reduced food and water consumption; multiple lesions on nose and muzzle; difficulty breathing; ears purple, drooping, with multiple lesions (10-20 each ear); animals euthanized due to severity of infection (day 10)	Reduced food and water consumption; animals euthanized due to severity of infection (day 11)	Primary lesion large, black but starting to dry out and cavitate; eyes good, slight discharge from 1 eye of 1 animal; multiple (4-10) lesions in each ear
12-19			Animals healing, primary lesions dried out and scabby, small healed lesions in ears