FIG. 7.

Replication of challenge virus in the genital mucosa of immunized mice. Groups of B7KO mice were immunized s.c. with the indicated virus or were left unimmunized, then challenged intravaginally 1 month later with wild-type HSV-2. BALB/c mice immunized with 5BlacZ were a positive control for immunization. Titers from daily swabs of the vagina were determined for the viral titer shed from the mucosa. Data are the geometric means ± SEM for 10 to 15 mice per experimental group and are the combined results of two independent experiments. The dashed line indicates the limit of detection. *, P ≤ 0.0001 for days 2 through 5 comparing 5B80 or 5B86 to B7KO-5BlacZ; **, P = 0.0205 for 5B80 compared with 5B86 on day 5. P ≤ 0.00001 for days 2 through 4 comparing 5B86 to BALB/C-5Blacz.