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Virus titers in BALB/c mouse tissue at 1, 3, and 6 days after inoculation (d.p.i.). (A) Titers (log10 EID50 /ml) in blood, brain, and lungs after inoculation with 10 PFU of recombinant VN1203, VN1203-H274Y, or VN1203-N294S virus. (B) Titers (log10 EID50 /ml) in lungs after inoculation with 100 PFU of recombinant PR8, PR8-H274Y, or PR8-N294S virus. Each data point represents the value in an inoculated mouse, and the lines represent the mean values from three mice.
