TABLE 2.
Susceptibility of the recombinant H5N1 and H1N1 influenza viruses to NAIs
| Recombinant virus | NA inhibition assay results for:
|
|||
|---|---|---|---|---|
| Oseltamivir
|
Zanamivir
|
|||
| Mean IC50 ± SD (nM)a | Fold changeb | Mean IC50 ± SD (nM) | Fold change | |
| H5N1 viruses | ||||
| VN1203 | 0.3 ± 0.1 | 1 | 1.4 ± 0.4 | 1 |
| VN1203-H274Y | 501.7 ± 135.4 | 1,672 | 2.4 ± 0.7 | 2 |
| VN1203-N294S | 6.4 ± 2.0 | 21 | 4.3 ± 0.7 | 3 |
| H1N1 viruses | ||||
| PR8 | 4.2 ± 0.9 | 1 | 0.7 ± 0.1 | 1 |
| PR8-H274Y | 1,226.6 ± 371.0 | 292 | 0.8 ± 0.1 | 1 |
| PR8-N294S | 350.1 ± 10.4 | 83 | 2.3 ± 0.1 | 3 |
a
The concentration of NAIs that reduced NA activity by 50% relative to a reaction mixture containing virus but no inhibitor. Values are from three independent experiments.
b
Multiple of the value obtained for the recombinant wild-type virus.