FIG. 2.
Plasma viral loads and CD4 counts of animals receiving ART. Animals were challenged intravenously with 1 × 105 infectious units of RT-SHIVmne at week 0. (A) Three animals were given EFV monotherapy for 3 days during week 13. Daily ART was administered for 20 weeks (17 to 37 weeks postinfection). Animal M03250 was euthanized after virologic failure at week 26. ART was discontinued for the other two animals and reinitiated at week 40 or 41, continuing until week 45. (B) Three animals were given daily ART for 20 weeks (17 to 37 weeks postinfection). ART was discontinued and reinitiated at week 39, 40, or 41, continuing until week 45. (C) Absolute CD4 counts of the ART group animals were measured in the blood at multiple time points. Gray shading represents the time when animals received therapy. Arrows denote when ART was reinitiated for each animal after treatment interruption. The plasma virus decay kinetics are shown for the animals during the week of EFV monotherapy (week 13-14) (D) and the first week of combination therapy (week 17-18) (E). The viral loads are plotted relative to the last pretherapy value. Regression lines for all animals combined are shown for EFV monotherapy and combination therapy, along with the inferred half-lives (r2 values are 0.83 and 0.91, respectively).