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Systemic infections following repeated rectal exposure of rhesus monkeys to SIVmac251 or SIVsmE660. Monkeys were exposed by intrarectal inoculation for 6 successive weeks to cell-free virus using three monkeys/dose/challenge stock and doses of 6 × 107, 6 × 106, and 6 × 105 copies of virus. Monkeys were monitored for systemic infection on a weekly basis by assessing plasma SIV gag RNA levels.
