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Schematic illustration of rcDNA structural features and requirement for the conversion of rcDNA into cccDNA. Incompletely synthesized plus-strand DNA is indicated with dashed line. RNA primer for plus-strand DNA synthesis is shown as curved line, and sequence is shown in lowercase letters. Polymerase (pol) covalently linked to the 5′ end of minus-strand rcDNA is highlighted with a filled circle. Direct repeat (DR) sequences 1 and 2 are indicated.
