FIG. 9.
CCL21-induced migration of DCs is enhanced by ligation of EWI-2. Migration of mature DCs against 500 ng/ml SLC/CC21 was tested without antibodies added (1.09 × 105 ± 0.12 × 105 cells) or in the presence of various concentrations of the anti-EWI-2 mAbs 5E8, 6H5, and 8D3 or control IgG. Antibodies were present in both the upper and lower chambers. Numbers of migrated cells are given; ★ denotes a significant difference, with a P value of <0.05. Migration towards medium alone was 1.5 × 103 ± 1.5 × 103. Averages of quadruplicates from one representative donor (out of five) are shown.