FIG. 6.

Cyst formation and deregulation of STAT5 and IGFBPs in virgin MMTV-Skp2B females. (A) H&E staining of mammary gland from 5-month-old and 9-month-old virgin MMTV-Skp2B females. (B) The mammary glands from three transgenic females were selected based on the phenotypes indicated. The levels of STAT5, phospho-STAT5, and IGFBP-2 and -4 were determined by Western blotting (immunoblotting [IB]) and compared to the levels observed for wild-type females. Morphology abbreviations: C, cyst alone; C+P, cyst and pregnancy; P+L, pregnancy and lactation without cyst.