TABLE 1.
Mortality of BALB/c and C57BL/6 mice following ocular infection with HSV-gK3
| Virus | No. (%) of mice that died/no. infected with titer showna:
|
||||
|---|---|---|---|---|---|
| BALB/c
|
C57BL/6 (2 × 105) | ||||
| 2 × 102 | 2 × 103 | 2 × 104 | 2 × 105 | ||
| HSV-gK3 | 12/25 (48)b | 5/5 (100) | 5/5 (100) | 39/50 (78)b | 0/39 (0)b |
| dLAT2903 | 12/25 (48)b | 4/5 (80) | 5/5 (100) | 5/5 (100) | ND |
| McKrae | 2/5 (40) | 5/5 (100) | 5/5 (100) | 32/50 (64)b | 0/30 (0)b |
| HSV-gK3Rc | 2/5 (40) | 5/5 (100) | 5/5 (100) | 5/5 (100) | ND |
a
BALB/c or C57BL/6 mice were ocularly infected with the specified virus titers (PFU/eye), and mortality was determined 30 days after infection. ND, not done.
b
Data from four separate experiments.
c
HSV-gK3R rescued virus is a control virus with only the endogenous copy of gK (see Materials and Methods for details).