TABLE 2.

Impact of receptor affinity on virus-induced intercellular fusion^a

Virus	No. of syncytia ± SD counted in
	SKOV3ip.1 cells	TE671 cells
MV-aHER-6	9.1 + 6.7*b	3.6 + 1.6
MV-aHER-7	10.8 + 6.3*	5.4 + 1.6
MV-aHER-8	91.4 + 22.9	14.1 + 5.6
MV-aHER-9	132.6 + 52.6*	295.2 + 45.9*
MV-aHER-10	152.5 + 32.2*	320.1 + 74.6*
MV-aHER-11	156.2 + 28.3*	327.5 + 36.9*

^aSKOV3ip.1 cells and TE671 cells were infected with each of the HER2-retargeted measles viruses (MOI of 0.1), and the syncytial indices were determined. Briefly, at 72 h postinfection, cells were fixed and stained with Hoechst 33342. Numbers of nuclei in each syncytium were counted (syncytial index, n = 10 syncytia counted). TE671 cells express 40-fold lower levels of HER2 receptors. Values shown are means ± standard deviations (SD). P value was determined by one-way analysis of variance.

^b*, indicates a significant difference (P < 0.01) between the test group and MV-αHER-8-infected cells, using Dunnett's multiple comparison test.