TABLE 5.

Viremia following challenge with 10⁶ MID₅₀ DENV-4 in rhesus monkeys passively administered IgG 5H2 ΔD^a

Monkey	IgG 5H2 ΔD (0.9 mg/ml) administration	Viremia		Peak virus titer (FFU/ml)b
		Onset day	Duration (days)
RH690	−	2	6	230
RH670	−	2	5	10
RH692	+	6	6	801
RH688	+	6	4	2001,2
RH693	+	4	5	2102
RH685	+	8	2	10

^aRhesus monkeys that received 0.9 mg/kg of IgG 5H2 ΔD (approximately 300 PRNT₅₀/ml) intravenously were challenged subcutaneously with 1 × 10⁶ MID₅₀ DENV-4 24 h later. Control monkeys (RH690 and RH670) that received the diluent PBS were similarly challenged. Monkey serum samples obtained on days 1 to 12 postchallenge were analyzed for viremia by focus-forming assay.

^bPutative neutralization escape mutant viruses recovered had Lys₁₇₄-Arg (1) and Lys₁₇₄-Glu (2) mutations.