TABLE 2.
Infectivity assays of the brains of nontreated mice or cpd-B-treated mice
| Dilution | Nontreated mice (63 dpia)
|
cpd-B treated mice (63 dpi)
|
cpd-B treated mice (154 dpi)
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Mouse no. | No. of diseased mice/total | Mean incubation time (days) ± SD | Mouse no. | No. of diseased mice/total | Mean incubation time (days) ± SD | Mouse no. | No. of diseased mice/total | Mean incubation time (days) ± SD | |
| 102 | cnt-1 | 8/8 | 77.4 ± 4.5 | bc-1d | 7/7 | 284.1 ± 54.6 | bl-1 | 7/7 | 122.0 ± 14.0 |
| bc-2e | 8/8 | 136.8 ± 19.2 | bl-2f | 7/7 | 92.6 ± 8.9 | ||||
| bl-3 | 7/7 | 89.1 ± 4.0 | |||||||
| 103 | cnt-1 | 8/8 | 84.4 ± 6.9 | bc-1d | 0/7 | >140c | bl-1 | 5/9 | >140c |
| cnt-2 | 6/6 | 75.3 ± 2.4 | bc-2e | 1/8 | >140c | bl-2f | 7/7 | 97.4 ± 9.6 | |
| cnt-3 | 7/7 | 75.7 ± 7.4 | bl-3 | 9/9 | 101.6 ± 7.4 | ||||
| 104 | cnt-1 | 7/7 | 88.4 ± 7.3 | bc-1d | 1/8 | >140c | bl-1 | 1/9 | >140c |
| bc-2e | 1/9 | >140c | bl-2f | 3/7 | >140c | ||||
| bl-3 | 3/7 | >140c | |||||||
| 105 | cnt-1 | 6/6 | 155.7 ± 55.3 | ||||||
| cnt-2 | 7/7 | 105.4 ± 16.5 | |||||||
| cnt-3 | 7/7 | 95.9 ± 7.1 | |||||||
| 106 | cnt-1 | 1/7 | >420b | ||||||
| 107 | cnt-1 | 3/7 | >420b | ||||||
| 108 | cnt-1 | 1/7 | >420b | ||||||
| 109 | cnt-1 | 2/7 | >420b | ||||||
a
Days after cerebral inoculation.
b
Observed up to 420 days postinoculation.
c
Observed up to 140 days postinoculation.
d
Mouse for the sample in the left lane of 0.2% cpd-B at 63 dpi in Fig. 4A.
e
Mouse for the sample in the right lane of 0.2% cpd-B at 63 dpi in Fig. 4A.
f
Mouse for the sample of the rightmost lane of 0.2% cpd-B at 154 dpi in Fig. 4A.