TABLE 2.

Reactions of MAbs with escape mutants of A/Mallard/Pennsylvania/10218/84 (H5N2) virus in HI assay

Escape mutant	HA amino acid changea		Reactivity with MAbb:
	H3 numbering	H5 numbering	VN04-2	VN04-9	VN04-10	VN04-13	VN04-15	VN04-16	777/1
m46(7)	N129D	N124D	<	0	0	0	0	0	0
m46(8)	K157M	K153M	0	0	0	0	−2	0	0
m55(2)	K156N	K152M	0	<	<	0	0	<	−4
m58(1)	D131N	D126N	0	−2	<	0	<	<	−1
m24B9	R144G	R140G	0	0	0	0	<	0	0
m46(7)-55	N129D, K156T	N124D, K152T	<	<	0	0	−2	<	0
m46(7)-55-24B9	N129M, K156T, P140L	N124D, K152T, P136L	<	<	−2	<	<	<	−2
m55(2)-24B9	K156N, N142K	K152T, N138K	0	<	<	0	<	<	<
m58(1)-24B9	D131N, S145P	D126N, S141P	0	−2	<	<	<	<	<

^aSee Table 1, footnote a.

^bDesignations are the same as in Table 1. Values are the differences in log₂ units between the HI titers of MAbs in the reactions with the wild-type A/Mallard/Pennsylvania/10218/84 (H5N2) virus and with its escape mutants.