TABLE 4.
Amino acid changes in HA of the H5N1 viruses
| HA phylogeny | Virus | Amino acid at positiona:
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 125
|
129
|
133
|
142
|
144
|
145
|
158
|
159
|
160
|
163
|
166
|
178
|
185
|
193
|
||
| 120 | 124 | 129 | 138 | 140 | 141 | 154 | 155 | 156 | 159 | 162 | 174 | 181 | 189 | ||
| Clade 1 | A/Vietnam/1203/04 | S | S | L | Q | K | S | N | S | T | T | R | V | P | K |
| A/Vietnam/1194/04 | S | S | L | Q | K | S | N | S | T | T | R | V | P | K | |
| A/Hong Kong/213/03 | N | S | L | Q | K | S | N | N | A | T | R | V | P | R | |
| Clade 2A, subclade 1 | A/Chicken/Indonesia/PA/03 | S | D | S | Q | K | S | N | S | A | T | R | V | P | R |
| A/Chicken/Malang/BBVet-IV/04 | S | N | S | Q | K | S | N | S | A | T | R | V | P | R | |
| A/Chicken/Jogjakarta/BBVet-IX/04 | S | D | S | L | R | S | N | S | T | I | R | V | P | K | |
| Clade 2E, subclade 2 | A/Whooper swan/Mongolia/244/05 | S | D | S | Q | R | S | D | N | A | T | R | V | P | R |
| Clade 2F, subclade 3 | A/Duck/Laos/3295/06 | S | D | S | Q | T | P | N | N | T | T | R | I | S | K |
a
Amino acid numbering in the top row is based on H3 HA. Amino acid numbering in the bottom row is based on H5 HA. Amino acid substitutions with respect to the HA of A/Vietnam/1203/04 (H5N1) are indicated in boldface. Amino acid positions changed in the HA of escape mutants are indicated in italics.