TABLE 1.

CD4/CD8 ratios in peripheral blood and spleen and CD4⁺ CD8⁺ cells in thymus of groups of uninfected and HIV-1-infected mice^a

Group and mouse identification no.	No. of days after inoculation	CD4/CD8 ratio		% of CD4+ CD8+ cells in thymus	No. of RNA viral copies/ml
		Blood	Spleen
Uninfected control group (n = 15)		2.92 ± 1.68	2.78 ± 1.46	67.8 ± 20.5
HIV-1JRCSF-infected group
1	30	1.86	0.88	77.1	9,078
2	30	0.46	0.53	12.5	7,703
3	33	2.61	2.17	85.7	223,020
4	63	0.17	0.27	25.5	9,965
5	63	0.36	0.44	27.2	8,734
6	63	0.18	0.88	69.6	42,198
7	90	0.03	0.37	82.5	24,441
8	90	0.30	0.79	84.6	24,454
9	90	1.77	1.55	56.9	80,636
10	109	0.20	0.17	43.4	470,392
11	116	0.09	0.78	11.8	299,080
HIV-1MNp-infected group
1	31	0.82	0.44	34.6	3,709,520
2	31	1.02	0.61	90.2	219,971
3	31	1.64	1.57	78.2	135,592
4	59	0.21	0.38	35.4	78,848
5	59	0.10	0.07	77.0	1,039,716
6	87	0.20	0.40	0.5	49,080
7	87	0.19	0.08	11.7	121,817
8	91	0.04	0.04	82.9	30,706
9	91	0.28	0.10	1.2	7,407
10	109	0.00	0.21	2.8	17,310
HIV-1NL4-3-infected group
1	32	1.01	0.81	64.5	195,375
2	32	0.03	0.05	4.6	770,721
3	60	0.21	0.13	3.9	1,108,003
4	60	0.14	NDb	ND	328,375
5	87	0.03	0.04	1.0	201,207
6	92	0.03	0.17	11.1	90,831
7	92	0.03	0.03	1.4	135,514
8	112	0.30	0.23	0.2	325,202

^aTwenty-nine mice inoculated with R5-tropic HIV-1_JRCSF (n = 11), X4-tropic HIV-1_MNp (n = 10), or X4-tropic HIV-1_NL4-3 (n = 8) were sacrificed 161 to 249 days after HSC transplantation. Fifteen uninfected control mice were sacrificed 174 to 249 days after transplantation, and results for the control group are expressed as means ± standard deviations.

^bND, not determined because of a lack of cells.