TABLE 2.
Fab 3674 antibodies neutralize diverse HIV-1 subtype B pseudotypes
| HIV-1 Env strain | IC50 (μg/ml)a for:
|
|||
|---|---|---|---|---|
| bF-3674 | mF-3674 | 2F5 | 4E10 | |
| Laboratory adapted | ||||
| HXB2 | 9 ± 1 | 30 ± 3 | 0.4 ± 0.1 | 0.3 ± 0.1 |
| YU2 | 114 ± 18 | 203 ± 25 | 18.0 ± 5 | 24.8 ± 7 |
| JR CSF | 78 ± 20 | 106 ± 30 | 5.3 ± 1.5 | 8.6 ± 2.3 |
| SF162 | 218 ± 62 | NA | 8.4 ± 1.5 | 6.6 ± 0.1 |
| 89.6 | 94 ± 18 | NA | ||
| Primary | ||||
| Bal01 | 29 ± 9 | 89 ± 9 | ||
| BaL26 | 294 ± 75 | 113 ± 20 | ||
a
NA, no activity: in the range of Fab concentrations tested, neutralization was too weak to reliably determine an IC50 value.