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. 2007 Sep 17;27(23):8205–8214. doi: 10.1128/MCB.00785-07

FIG. 4.

FIG. 4.

Chromosomal abnormalities observed by two-color FISH on metaphase spreads. (A) Representative examples of chromosomal abnormalities. Shown are the DAPI stain, telomere probe (telo), and merge. The white arrow points to a chromosomal fragment. Con, control. (B to E) Graphs showing the total number of events per total number of metaphase spreads for single-chromatid telomere loss (B), fragments/breaks (C), telomere associations (D), and telomere fusions (E). The number may be greater than 1 if enough metaphase spreads have multiple events (see Table 2). Statistical analysis based on the likelihood ratio test comparing groups listed in Table 2: 1 versus 2, 3, and 4, P = 0.0513 (single-chromatid telomere loss), P < 0.0001 (fragments/breaks), P = 0.4469 (telomere associations), and P < 0.0001 (telomere fusions); 1 versus 5, P = 0.3570 (single-chromatid telomere loss), P < 0.3141 (fragments/breaks), P = 0.3338 (telomere associations), and P = 0.2814 (telomere fusions); 1 versus 9, P < 0.0001 (single-chromatid telomere loss), P = 0.0017 (fragments/breaks), P < 0.0001 (telomere associations), and P = 0.2959 (telomere fusions); 2, 3, and 4 versus 6, 7, and 8, P < 0.0001 (single-chromatid telomere loss), P < 0.0419 (fragments/breaks), P < 0.0001 (telomere associations), and P = 0.5530 (telomere fusions).