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. 2007 Oct 1;27(23):8318–8329. doi: 10.1128/MCB.01209-07

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Copyright © 2007, American Society for Microbiology

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FIG. 6. — Otx2 is required for retinal photoreceptor and bipolar-cell development. (A) Viral constructs used to express Cre. pLIA was derived from Moloney murine leukemia virus and was designed to express a marker gene, AP (alkaline phosphatase), through an internal ribosome entry site (IRES) sequence and another gene under the control of the long terminal repeat (LTR) promoter. (B to F) Percentages of clones containing rods only (B) and at least one rod (C), amacrine cell (D), bipolar cell (E), and Müller glia (F) out of the total number of clones infected by LIA or LIA-Cre virus. (G) Average number of cells contained in each clone infected by LIA or LIA-Cre virus. Error bars represent the standard deviations of the means. *, P < 0.0001; **, P < 0.01 (Student's t test).