TABLE 1.
Liver function tests and metabolic parameters in plasma of LRH-1hepL2/L2 and LRH-1hep−/− micea
| Test or parameter | Result for:
|
|
|---|---|---|
| L2/L2 (n = 9) | hep−/− (n = 9) | |
| Liver function tests | ||
| Total protein (g/liter) | 61.9 ± 0.6 | 64.3 ± 0.9* |
| Albumin (g/liter) | 31.4 ± 0.9 | 30.6 ± 0.8 |
| Bilirubin (μmol/liter) | 1.9 ± 0.4 | 2.2 ± 0.6 |
| Aspartate aminotransferase (U/liter) | 51.2 ± 2.2 | 49.4 ± 3.5 |
| Alanine aminotransferase (U/liter) | 25.0 ± 2.6 | 27.9 ± 7.0 |
| Alkaline phosphatase (U/liter) | 84.2 ± 5.3 | 78.6 ± 4.8 |
| Metabolic parameters | ||
| Total cholesterol (mmol/liter) | 3.5 ± 0.2 | 3.8 ± 0.3 |
| HDL-cholesterol (mmol/liter) | 2.1 ± 0.1 | 2.2 ± 0.2 |
| LDL-cholesterol (mmol/liter) | 0.5 ± 0.0 | 0.7 ± 0.1 |
| Triglycerides (mmol/liter) | 1.5 ± 0.1 | 1.7 ± 0.1 |
| Free fatty acids (mEq/liter) | 2.4 ± 0.2 | 2.7 ± 0.2 |
| Glucose (mmol/liter) | 15.7 ± 1.0 | 14.6 ± 0.7 |
| Insulin (μg/liter) | 0.7 ± 0.2 | 0.5 ± 0.2 |
a
Mice were fasted for 3 h and parameters were determined 3 weeks after tamoxifen injection (*, P < 0.05). HDL, high-density lipoprotein; LDL, low-density lipoprotein.