. Author manuscript; available in PMC: 2008 Apr 1.

Published in final edited form as: Biochim Biophys Acta. 2006 Oct 5;1768(4):994–1005. doi: 10.1016/j.bbamem.2006.09.029

Table 2.

Examples of polymorphisms of GPCR associated with human diseases

Receptor	Polymorphisms	Examples of disease associations	Ref
β₁ Adrenergic receptor	Arg389Gly	Heart failure	[64, 71]
β₂ Adrenergic receptor	Multiple	Hypertension, Asthma	[118, 119]
β₃ Adrenergic receptor	Trp64Arg	Obesity	[120]
CC chemokine receptor 2 (CCR2)	Val64Ile	Delayed progression of AIDS	[121]
CC chemokine receptor 5 (CCR5)	Multiple	Associated with progression of AIDS	[33, 122]
Dopamine receptor 2 (D₂)	3’UTR52A/G	Associated with depression and anxiety	[123]
Dopamine receptor 3 (D₃)	Ser9Gly, Promoter SNPs	Haplotype associated with schizophrenia	[124]
Muscarinic receptor subtype 3 (M₃)	Promoter haplotype	Possible association with asthma and atopy	[125]
Neuropeptide S receptor (NPSR; also called GPR154, GPRA)	Haplotypes H1, H5 Asn107Ile, rs324981	Asthma susceptibility	[31, 32, 126]
P2Y₁₂	CA deletion at Codon 240	Associated with bleeding diathesis	[127]