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. Author manuscript; available in PMC: 2008 Oct 1.
Published in final edited form as: Dermatol Clin. 2007 Oct;25(4):643–x. doi: 10.1016/j.det.2007.06.012

Figure 1. Keratinocyte Beta2 Adrenergic Receptor Signaling Pathways.

Figure 1

(a) cAMP dependent signaling, (b) PP2A dependent pathway, (c) IP3 and PKC dependent pathway, and (d) pathway for beta2 adrenergic receptor blockade. The signaling depicted in the diagram is unique for keratinocytes. In other cell types, agonist activation of the receptor results in different downstream effector cascades. Dotted lines indicate signaling pathways where causal associations have been demonstrated but definitive mechanisms have not yet been defined (described in text).