Table 1. Proposed modulation of the keratinocyte beta2 adrenergic receptor and the catecholamine synthesis pathway in selected dermatological diseases.
| Disorder | Beta2AR expression/activation | 6BH4 | PNMT activity | Norepinephrine | Epinephrine |
|---|---|---|---|---|---|
| Atopic Dermatitis | NA | ↑ | ↓ | ↑ | ↓ |
| Vitiligo | ↑ | ↑ | ↓ | ↑ | ↓ |
| Psoriasis | ↓ | NA | ↑ | NA* | NA* |
NA= not yet definitively addressed.
*
Elevated circulating levels of norepinephrine and epinephrine have been reported in psoriasis but epidermal or keratinocyte levels have not yet been studied.