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Electron microscopic analysis of MEFs (a) and hepatocytes (b). (a) In the wild-type and heterozygous MEF nuclei, a largely continuous layer of heterochromatin in contact with the inner face of the nuclear envelope is visible. In the Lmna null nuclei, there are obvious discontinuities in this layer (orange box) that are juxtaposed to distensions of the nuclear membranes. (b) Similar discontinuities can be seen in the liver nuclei (arrow).
