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. 1999 Nov 29;147(5):945–958. doi: 10.1083/jcb.147.5.945

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Model of TMV infection in BY2 protoplasts. (1) Early in infection, TMV vRNA comes in close association with membranes of the ER, and vRNA-replicase complexes associated with ER are transported via microtubules to perinuclear positions. (2) Nascent vRNAs synthesize MP that remains associated with vRNA. (3) Formation and anchoring of large ER-derived structures containing MP, replicase, and vRNA that are stabilized by MP and microfilament interactions. (4) Microtubule-based transport system of vRNA-MP complexes towards the periphery of the cell to initiate cell-to-cell spread. (5) Protrusion of ER containing vRNA and MP through the plasma membrane. Note that the model is not drawn in scale.