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. 1999 Nov 29;147(5):1049–1062. doi: 10.1083/jcb.147.5.1049

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Resistance of motoneurons to the cell-killing effects of Fas activation is tightly regulated. Mouse motoneurons were cultured in the continued presence of BDNF, CNTF, and GDNF (NTFs) and then treated with the Fas activators sFasL (50 ng/ml) or anti-Fas antibodies (50 ng/ml). Motoneuron survival in all experiments was counted at 5 DIV, and expressed relative to the value in NTFs alone at that time. (A) Fas activators were added at 1 DIV only. (B) Fas activators were added at 1 and 3 DIV; no further motoneuron death was observed. (C) Fas activators were added at 3 DIV: all motoneurons became resistant to Fas activation. Histograms are representative of similar results obtained in three independent experiments. Error bars represent the mean ± range of duplicate values.