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. 2000 Feb 21;148(4):825–838. doi: 10.1083/jcb.148.4.825

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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A model proposing the role of tTG in cell adhesion. Association of integrins with tTG promotes cell adhesion and spreading due to formation of ternary adhesion complexes with Fn. (A) Integrin-mediated adhesion to Fn in the absence of tTG. (B) tTG enhances adhesion acting as a bridge between integrins and Fn. (C) tTG enhances adhesion by mediating the formation of ternary complexes where all three proteins interact with each other.