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. 2007 Oct 8;27(24):8807–8814. doi: 10.1128/MCB.01636-07

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Copyright © 2007, American Society for Microbiology

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FIG. 5. — SIRT3-deficient mice are viable and metabolically unremarkable under both fed and fasted conditions. (A) Normal liver histology in wild-type (WT) and SIRT3-deficient (KO) mice subject to an 18-hour fast. (B) SIRT3 deficiency does not affect mitochondrial content. Equal amounts of protein from total liver extracts generated from animals of the indicated genotypes representing two separate litters were probed with antibodies to TFAM to assess mitochondrial content and MnSOD, COX-IV, and cytochrome c as loading controls. (C) Body weight, adiposity, bone mineral density (BMD), and bone mineral content (BMC) are not affected by SIRT3 deficiency. (D) SIRT3-deficient and wild-type littermate control mice display similar measures of energy balance in both the fed and fasted states. Oxygen consumption (), respiratory exchange ratios (/), activity levels, and food intake were measured in metabolic cages. Data represent the means plus SEM for six animals per genotype.

Inline graphic — SIRT3-deficient mice are viable and metabolically unremarkable under both fed and fasted conditions. (A) Normal liver histology in wild-type (WT) and SIRT3-deficient (KO) mice subject to an 18-hour fast. (B) SIRT3 deficiency does not affect mitochondrial content. Equal amounts of protein from total liver extracts generated from animals of the indicated genotypes representing two separate litters were probed with antibodies to TFAM to assess mitochondrial content and MnSOD, COX-IV, and cytochrome c as loading controls. (C) Body weight, adiposity, bone mineral density (BMD), and bone mineral content (BMC) are not affected by SIRT3 deficiency. (D) SIRT3-deficient and wild-type littermate control mice display similar measures of energy balance in both the fed and fasted states. Oxygen consumption (), respiratory exchange ratios (/), activity levels, and food intake were measured in metabolic cages. Data represent the means plus SEM for six animals per genotype.