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. 2001 Apr 16;153(2):243–250. doi: 10.1083/jcb.153.2.243

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Involucrin-Dsg 3 transgenic mice have an abnormal stratum corneum. (A) Right two mice are transgenic pups, left two are normal littermates. Scaling of transgenics indicates an abnormal stratum corneum (all pups are 6-d old). (B) Histology (hematoxylin and eosin stain) of nontransgenic tail skin shows typical basket weave stratum corneum (brackets). (C) Histology of transgenic tail skin shows normal living epidermis but compact and lamellar stratum corneum (brackets). (D) Histology of normal palate shows compact and lamellar stratum corneum, similar to that seen in the transgenic epidermis (brackets). (B–D) 4-d-old pups, original magnification 125×.