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. 2001 Apr 16;153(2):243–250. doi: 10.1083/jcb.153.2.243

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Dsg 3 in the superficial epidermis of transgenic mice results in premature dissolution of desmosomes and cleft formation in the stratum corneum. (A) Dissolution of desmosomes begins at the stratum granulosum (SG)–stratum corneum (SC) interface. Desmosomal detachment (single arrows) results in cleft formation (*) at all levels of the stratum corneum. D, normal-appearing desmosomes. (B) Normal-appearing desmosomes in control stratum corneum. (C) Normal mucous membrane (lip) also reveals early cleft formation. Note small (small *) clefts at SG–SC interface and larger clefts (large *) at higher levels. Bar: 0.5 μm (A and B), 1 μm (C). Osmium tetroxide postfixation.