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. 1999 Sep 6;146(5):1045–1060. doi: 10.1083/jcb.146.5.1045

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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(A) Time-lapse sequence showing a myosin Va-Cy3 antibody-labeled spot (particle) (arrowhead) making anterograde movements along a rat SCG neurite. Only the small relatively dim spots (visible using a 100× 1.4 NA lens) such as the one shown in this sequence, exhibited rapid movements. Large bright spots seen in cell bodies and proximal neurite segments of neurons injected with larger amounts of antibody never made rapid movements. The interval between images is 6 s. (B) The displacement of individual myosin Va-Cy3 antibody spots (particles) at sequential time points is shown. Positive values indicate movement away from the cell body, negative values indicate movement towards the cell body. Movement is saltatory; pauses and direction reversal can occur for varying periods of time. All examples are from rat SCG neurons. (C) The maximum rates of particle movements from untreated neurons (rat, n = 27; mouse, n = 13) show a wide distribution. Bar, 6.4 μm.