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. 1999 Sep 6;146(5):1147–1160. doi: 10.1083/jcb.146.5.1147

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The α6β4 integrin colocalizes with the EGF receptor and phosphotyrosine in ruffles and lamellipodia but not in hemidesmosomes. A431 cells were plated on laminin-1 for 1 h and then either stimulated with EGF (1 ng/ml) for 15 min (A and C) or left untreated (B). All cells were processed for double-staining with the α6-specific rat mAb GoH3 (red) and mouse Abs specific for either the EGFR (A, green) or phosphotyrosine (PY20; B and C, green). Yellow depicts colocalization of two antigens. Arrowheads indicate colocalization in lamellipodia and ruffles, and small arrows indicate focal adhesion-like structures. Large arrow indicates hemidesmosome area. Bar, 10 μm.