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. 1999 Sep 6;146(5):1133–1146. doi: 10.1083/jcb.146.5.1133

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Carboxy-terminal regions of the MuSK ectodomain are required for association with AChR clusters in myotubes. (a) MuSK constructs, numbered as in Fig. 2, which were tested for their ability to associate with AChR clusters in MuSK ^−/− muscle cells. To the right of each construct is indicated whether it was concentrated at spontaneous or agrin-induced clusters. NA, not applicable, because agrin did not induce AChR clusters in these cells. (b–i) MuSK and AChR localization in cells transfected with expression vectors encoding MuSK constructs that colocalize (b and c, construct 1; d and e, construct 2; f and g, construct 5) or do not colocalize (h and i, construct 6) with AChRs. Cells were treated with agrin for 18 h, and then doubly stained with anti-mouse MuSK antibodies (b, d, f, and h) and rBTX (c, e, g, and i). Arrows indicate corresponding points in the two images of each field. Bar, 20 μm.