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. 1999 Sep 6;146(5):1087–1096. doi: 10.1083/jcb.146.5.1087

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Inhibition of polymerization and depolymerization with PAO completely stops motility. a and b, A crawling sperm before and 15 s after treatment with 30 μM PAO. After 3 min in PAO (c), there was no movement of the cell or treadmilling of its cytoskeleton. For example, the arrows in b and c indicate a bend in a fiber complex that did not change position while the cell was incubated in PAO. However, within 15 s after washing the cell with HKB containing 5 mM dimercaptopropanol (a PAO antagonist), locomotion and cytoskeletal treadmilling resumed (d). Bar, 10 μm.