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. 1999 Sep 6;146(5):1005–1018. doi: 10.1083/jcb.146.5.1005

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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The Msps protein belongs to the dis1-TOG family. (a) Sequence comparison between Msps and human TOGp. Only identical residues are marked. Five putative cdc2 phosphorylation sites (S/TPXK/R) were identified in the COOH-terminal portion of the Msps protein (amino acids 1,564, 1,568, 1,803, 1,859, and 2,029). (b) Domain structure of members of the dis1-TOG family. From the top, human TOGp, D. melanogaster Msps, C. elegans ZYG-9, S. pombe Dis1, and S. cerevisiae STU2. Shaded boxes represent repeats (see c) common to all the dis1-TOG family. The COOH-terminal portions of the human and Drosophila proteins can be divided into two domains, one of which is also conserved in C. elegans protein, and the other found in Drosophila and vertebrates. (c) Amino acid sequences of the NH₂-terminal repeats from the different proteins are aligned. Numbers in parentheses indicate the length of intervening amino acid sequences. The sequence of msps gene is available from GenBank/EMBL/DDBJ under accession number AJ249115.