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. 1999 Sep 6;146(5):917–928. doi: 10.1083/jcb.146.5.917

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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p193 is 1724 aa in length and can be divided into four domains (I–IV). A PROSITE sequence motif search identified the NH₂ terminus (aa 1–94) as a BRCT domain (dark grey, I). aa 209–563 share 28% sequence identity with the catalytic subunit of PARP (light grey, II). aa 616–706 and 877–919 share 30 and 29% identity, respectively, with the inter–α-trypsin inhibitor heavy chain (broken boxes, III), although the significance of this homology is not clear at present. The COOH terminus (aa 1562–1724) defines the region necessary for interaction with the MVP (medium gray, IV). The nucleotide sequence data are available from GenBank/EMBL/DDBJ under accession no. AF158255.