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Second-order rate constants for OA-NO2 reaction with thiols of different pKa
| Thiol | pKaa | kapp |
|---|---|---|
| M−1s−1 | ||
| Cysteine methyl ester | 6.7 | 442 ± 9 |
| Penicillamine | 7.9 | 71 ± 5 |
| Cysteine | 8.3 | 267 ± 33 |
| Glutathione | 8.8 | 183 ± 6 |
| Homocysteine | 8.9 | 100 ± 2 |
| N-Acetyl-cysteine | 9.5 | 28 ± 3 |
| Dihydrolipoic acidb | 10.7 | 13 ± 3 |
Data for thiol pKa were obtained from Ref. 46.
Calculated assuming both thiols are equally reactive with OA-NO2.
