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. 1998 Sep 29;95(20):11715–11720. doi: 10.1073/pnas.95.20.11715

Figure 3.

Figure 3

(A) Mitochondrial electron transport and ROS generation. Antimycin A and myxothiazol alter ROS generation by changing the lifetime of ubisemiquinone. Sites of inhibition are indicated with boxes. (B) DCF fluorescence in wild-type Hep3B cells during hypoxia (2% O2/5% CO2/93% N2) and DPI (3 μM). (C) DCF fluorescence in wild-type cells during hypoxia (2% O2/5% CO2/93% N2) and myxothiazol (100 ng/ml). (D) DCF fluorescence in wild-type cells during hypoxia (2% O2/5% CO2/93% N2) and rotenone (3 μg/ml). (E) DCF fluorescence in wild-type cells during hypoxia (2% O2/5% CO2/93% N2) and antimycin A (3 μg/ml). Graphs are representative examples.