Table 1.
Comparison of biophysical properties of anti-Kv2.1-sensitive and rStromatoxin-1 (ScTx)-sensitive currents
| Activation | AB sensitive1 | ScTx sensitive2 |
|---|---|---|
| % block | 33 ± 5.7 (11) | 58 ± 2.1 (22) |
| τ at −10 mV (ms) | 75 ± 25 (4) | 69 ± 21 (4) |
| V1/2 (mV) | 3.8 ± 1.1 (4) | −3.1 ± 0.8 (4) |
| Slope (mV) | 13 ± 0.7 (4) | 10.5 ± 0.6 (4) |
| Inactivationτ | ||
| at −10 mV (s) | 5.2 ± 1.5 (5) | 7.8 ± 2.1 (11) |
| V1/2 (mV) | −62 ± 3.0 (6) | −60 ± 1.6 (7) |
| Slope (mV) | 11.5 ± 1.1 (6) | 12.5 ± 0.2 (5) |
| Recovery (at 100 mV) | ||
| (τ (ms)) | 793 ± 123 (9) | 980 ± 67 (8) |
| Erev (mV) | −- | −91.8 ± 2.4 (3) |
1
AB, anti-Kv2.1, combined polyclonal (n = 8) and monoclonal (n = 3).
2
500–600 nm ScTx. Values are mean ± s.e.m.