Table 1.
Basic characteristics of the transgenic model versus wildtype control
| lacZ transgenic | non-transgenic | |
|---|---|---|
| Blood cell count | ||
| Ery (x 106 mm−3) | 9.475 ± 0.72 | 9.115 ± 0.68 |
| Leuc (x 103 mm−3) | 6.915 ± 0.66 | 6.605 ± 0.62 |
| Hb (g l−1) | 8.435 ± 0.74 | 8.35 ± 0.59 |
| Ht (%) | 0.46 ± 0.05 | 0.435 ± 0.06 |
| MCV (fl) | 48.78 ± 2.78 | 47.93 ± 3.01 |
| MCHC (%) | 4.52 ± 0.33 | 4.77 ± 0.52 |
| Thromb (x 104 mm−3) | 111.60 ± 55.01 | 122.35 ± 74.45 |
| Clinical chemistry | ||
| Creatinine (mmol l−1) | 34.40 ± 7.11 | 35.25 ± 9.34 |
| Sodium (mmol l−1) | 148.00 ± 2.58 | 147.25 ± 6.37 |
| Urea (mmol l−1) | 16.40 ± 4.51 | 15.04 ± 5.77 |
| Protein (mg dl−1) | 64.05 ± 7.48 | 63.25 ± 4.66 |
| Histological evaluation | ||
| Interstitial fibrosis | 1.76 ± 0.14 | 1.72 ± 0.09 |
| Glomerulosclerosis | 2.21 ± 0.29 | 2.16 ± 0.23 |
Basic characterization of our transgenic model versus wild-type control: clinical chemistry, peripheral blood count and kidney histology. No differences between prepro-ET-1 lacZ transgenic and non-transgenic mice were detectable. Ery = erythrocytes, Leuc = leucocytes, Hb = haemoglobin, Ht = haematocrit, MCV = mean corpuscular volume, MCHC, mean corpuscular haemoglobin concentration, Thromb = thrombocytes.